Clinical significance of estrogen receptor phosphorylation.

  title={Clinical significance of estrogen receptor phosphorylation.},
  author={Leigh C. Murphy and Srinivas V Seekallu and Peter Hamilton Watson},
  journal={Endocrine-related cancer},
  volume={18 1},
Multiple sites of phosphorylation on human estrogen receptor α (ERα) have been identified by a variety of methodologies. Now with the emerging availability of phospho-site-specific antibodies to ERα, the relevance of phosphorylation of ERα in human breast cancer in vivo is being explored. Multiple phosphorylated sites in ERα can be detected in multiple breast tumor biopsy samples, providing evidence of their relevance to human breast cancer in vivo. Published data suggest that the detection in… CONTINUE READING


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