Clinical significance of determination of surrogate markers of angiogenesis in breast cancer.

@article{Gasparini2001ClinicalSO,
  title={Clinical significance of determination of surrogate markers of angiogenesis in breast cancer.},
  author={Giampietro Gasparini},
  journal={Critical reviews in oncology/hematology},
  year={2001},
  volume={37 2},
  pages={
          97-114
        }
}
Compelling experimental and clinical data support the concept that breast carcinoma, as most of the other solid tumors, needs to develop the angiogenic phenotype for invasiveness, progression and metastasis. Several studies have determined intratumoral microvessel density by panendothelial markers and immunohistochemical techniques, with most of them showing that the degree of vascularity is associated with prognosis of the patients operated of early-stage invasive breast cancer. More recently… CONTINUE READING

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