Clinical significance of cyclin B1 protein expression in squamous cell carcinoma of the tongue.

@article{Hassan2001ClinicalSO,
  title={Clinical significance of cyclin B1 protein expression in squamous cell carcinoma of the tongue.},
  author={Khaled A. Hassan and A El-naggar and Jean – Charles Soria and D Liu and Waun Ki Hong and Li Mao},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 8},
  pages={2458-62}
}
PURPOSE Cyclin B1 plays an important role in control of the G(2)-M transition of the cell cycle. We have shown recently that overexpression of cyclin B1 is associated with poor outcome in patients with early stage squamous cell carcinoma (SCC) of the lung. EXPERIMENTAL DESIGN To determine the role of cyclin B1 in SCC of the tongue, we analyzed tumor specimens from 41 patients with stage II-IV SCC of the tongue who underwent curative surgery using immunohistochemistry. RESULTS The median… CONTINUE READING
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