Clinical significance of central nervous system involvement at diagnosis of pediatric acute myeloid leukemia: a single institution's experience

@article{Abbott2003ClinicalSO,
  title={Clinical significance of central nervous system involvement at diagnosis of pediatric acute myeloid leukemia: a single institution's experience},
  author={Brian L. Abbott and Jeffrey E. Rubnitz and Xin Tong and Deo Kumar Srivastava and C-H. Pui and Raul C. Ribeiro and Bassem I. Razzouk},
  journal={Leukemia},
  year={2003},
  volume={17},
  pages={2090-2096}
}
To determine the clinical significance of central nervous system (CNS) involvement at the time of diagnosis of pediatric acute myeloid leukemia (AML), we analyzed clinical features and outcomes of 290 patients treated consecutively on four institutional trials (AML80, AML83, AML87, and AML91). CNS status was classified as CNS1 (no blast cells in CSF; n=205), CNS2 (<5 WBC/μl CSF with blast cells; n=37), or CNS3 (⩾5 WBC/μl CSF with blast cells, or signs of CNS involvement; n=48). Patients with… CONTINUE READING
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