Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.

@article{Wright2004ClinicalSO,
  title={Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.},
  author={Shirley Wright and David S. Sanders and Alan Joseph Lobo and Lynne Lennard},
  journal={Gut},
  year={2004},
  volume={53 8},
  pages={1123-8}
}
BACKGROUND AND AIMS There are conflicting reports on the role of azathioprine (AZA) thioguanine nucleotide (TGN) metabolites in optimising therapy for inflammatory bowel disease (IBD). The aim of this study was to investigate TGN intrapatient variation, and the relationship between TGN concentrations and disease activity in IBD patients taking long term constant dose AZA. METHODS TGN and methylmercaptopurine nucleotide (MeMPN) concentrations were measured at intervals over a two year period… CONTINUE READING

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6 - mercaptopurine metabolite profiles provide a biochemical explanation to 6 - mercaptopurine resistance in patients with inflammatory bowel disease

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