Clinical significance of TTF‐1 protein expression and TTF‐1 gene amplification in lung adenocarcinoma

@inproceedings{Barletta2009ClinicalSO,
  title={Clinical significance of TTF‐1 protein expression and TTF‐1 gene amplification in lung adenocarcinoma},
  author={Justine A Barletta and Sven Perner and Anthony John Iafrate and Beow Yong Yeap and Barbara A. Weir and Laura Adele Johnson and Bruce Evan Johnson and Matthew Meyerson and Mark A. Rubin and William D Travis and Massimo F. Loda and Lucian R. Chirieac},
  booktitle={Journal of cellular and molecular medicine},
  year={2009}
}
The majority of lung adenocarcinomas express the lineage-specific thyroid transcription factor-1 (TTF-1). We recently reported that in a subset of lung adenocarcinomas the TTF-1 gene is amplified. Although the prognostic significance of TTF-1 expression has been previously investigated, the significance of TTF-1 amplification has not been established. We studied 89 consecutive patients with lung adenocarcinomas treated by surgery at Brigham and Women's Hospital between 1997 and 1999 and… CONTINUE READING
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