Clinical significance of Rho GDP dissociation inhibitor 2 in colorectal carcinoma

Abstract

Small GTPase proteins, including RhoA, RhoB, RhoC, Rac1, and cdc42, are important molecules for linking cell shape and cell-cycle progression because of their role in both cytoskeletal arrangements and mitogenic signaling. Over-expression of wild-type or constitutively active forms of RhoA has been shown to induce invasive behavior in non-invasive rat… (More)
DOI: 10.1007/s10147-011-0270-y

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