Clinical significance of Iroquois Homeobox Gene - IRX1 in human glioma.

@article{Zhang2018ClinicalSO,
  title={Clinical significance of Iroquois Homeobox Gene - IRX1 in human glioma.},
  author={Pengxing Zhang and Nan Liu and Xiaoshan Xu and Zhen Wang and Yingduan Cheng and Weilin Jin and Xin Wang and Hongwei Yang and Hui Liu and Yongsheng Zhang and Yanyang Tu},
  journal={Molecular medicine reports},
  year={2018},
  volume={17 3},
  pages={
          4651-4656
        }
}
The present study aimed to investigate the location, expression and clinical significance of Iroquois homeobox gene (IRX1) in human glioma. The expression of IRX1 gene in glioma cell lines (U87, U373, LN229 and T98G) and normal brain tissue was detected via reverse transcription-polymerase chain reaction. The IRX1 protein in fresh glioma specimens, with the adjacent normal brain tissue, was quantified through western blotting. The archived glioma only specimens from the present hospital and… 
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References

SHOWING 1-10 OF 25 REFERENCES
Expression and methylation of Iroquois homeobox protein 1 in pancreatic cancer
TLDR
IRX1 mRNA expression is down-regulated in pancreatic cancer, and it is related with promoter CpG islands hypermethylation, according to analysis of IRX1 gene sequence.
Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma
TLDR
The hypermethylation of IRX1 was not only detected in primary gastric cancer tissues but also in the peripheral blood of Gastric cancer patients, suggesting IRX 1 could potentially serve as a biomarker for gastriccancer.
The genomic organization and function of IRX1 in tumorigenesis and development
TLDR
This review summarizes the recent discoveries on the genomic structure of IRX1 and the type classification in different species and focused on explaining the key role ofIRX1 in tumorigenesis, and development of tumor and influence in biological processes of metazoans, which it hopes will provide a better understanding of the mechanism of IRx1.
IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling.
TLDR
Together, these results identify IRX1 as a prometastatic gene, implicate IRX 1 hypomethylation as a potential molecular marker for lung metastasis, and suggest that epigenetic reversion ofIRX1 activation may be beneficial for controlling osteosarcoma metastasis.
Expression of Iroquois genes is up-regulated during early lung development in the nitrofen-induced pulmonary hypoplasia.
The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism
TLDR
It is demonstrated that IRX1 binds to the MLL-AF4 complex at target gene promotors and counteract its promotor activating function, which could help to improve new treatment options for t(4;11) leukemia patients.
Systematic Review of MicroRNAs and its Therapeutic Potential in Glioma
TLDR
Not only can miRNAs be used as biomarkers of glioma diagnosis and therapy, but also as novel targets ofglioma gene therapy as well as tumor suppressors or oncogenes in gliomas.
IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer
TLDR
Enforcing IRX1 expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-VM mechanisms, in addition to previously found cell growth and invasion.
Hypomethylation and hypermethylation of DNA in Wilms tumors
TLDR
The overall genomic hypomethylation frequently observed in cancers is probably not just a response or a prelude to hypermethylation elsewhere in the genome, which suggests that the DNA hypometHylation contributes independently to oncogenesis or tumor progression.
MicroRNA-218 inhibits glioma invasion, migration, proliferation, and cancer stem-like cell self-renewal by targeting the polycomb group gene Bmi1.
TLDR
Restoring the expression of miR-218, a microRNA commonly downregulated in glioma, dramatically reduces the migration, invasion, and proliferation ofglioma cells.
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