Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus

@article{Nishioka2001ClinicalSO,
  title={Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus},
  author={Kiyonori Nishioka and Yuichiro Doki and Hitoshi Shiozaki and Hiroyuki Yamamoto and Shinji Tamura and Tetsuyuki Yasuda and Yuichiro Fujiwara and Masahiko Yano and Hiroshi Miyata and Kentaro Kishi and Hitoshi Nakagawa and Awad Shamma and Morito Monden},
  journal={British Journal of Cancer},
  year={2001},
  volume={85},
  pages={412 - 421}
}
CDC25A, CDC25B and CDC25C belong to a family of protein phosphatases which activate the cyclin-dependent kinase at different points of the cell cycle. According to accumulating evidence, CDC25A and CDC25B seem to possess oncogenic properties. We have analysed these expressions by immunohistochemistry, western blot and RT-PCR in a series of 100 patients with squamous cell carcinoma of the oesophagus. When compared with non-cancerous cells, CDC25A and CDC25B were strongly expressed in the… CONTINUE READING
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