Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma

Abstract

Cell adhesion molecule 1 (CADM1/TSLC1) was recently identified as a novel cell surface marker for adult T-cell leukemia/lymphoma (ATLL). In this study, we developed various antibodies as diagnostic tools to identify CADM1-positive ATLL leukemia cells. In flow cytometric analysis, the percentages of CD4+CADM1+ double-positive cells correlated well with both the percentages of CD4+CD25+ cells and with abnormal lymphocytes in the peripheral blood of patients with various types of ATLL. Moreover, the degree of CD4+CADM1+ cells over 1% significantly correlated with the copy number of the human T-lymphotropic virus type 1 (HTLV-1) provirus in the peripheral blood of HTLV-1 carriers and ATLL patients. We also identified a soluble form of CADM1 in the peripheral blood of ATLL patients, and the expression levels of this form were correlated with the levels of soluble interleukin 2 receptor alpha. Moreover, lymphomas derived from ATLL were strongly and specifically stained with a CADM1 antibody. Thus, detection of CD4+CADM1+ cells in the peripheral blood, measurement of serum levels of soluble CADM1 and immunohistochemical detection of CADM1 in lymphomas would be a useful set of markers for disease progression in ATLL and may aid in both the early diagnosis and measurement of treatment efficacy for ATLL.

DOI: 10.1038/leu.2011.379
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@article{Nakahata2012ClinicalSO, title={Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma}, author={Shingo Nakahata and Yoshinobu Saito and Kousuke Marutsuka and Teruo Hidaka and K I Maeda and Katsuyoshi Hatakeyama and Toshifumi Shiraga and Akira Goto and Nami Takamatsu and Yujiro Asada and Atae Utsunomiya and Akihiko Okayama and Youko Kubuki and Kazutaka Shimoda and Yoshinori Ukai and Gene Kurosawa and K Morishita}, journal={Leukemia}, year={2012}, volume={26}, pages={1238-1246} }