Clinical significance of B7-H4 expression in matched non-small cell lung cancer brain metastases and primary tumors

@inproceedings{Li2013ClinicalSO,
  title={Clinical significance of B7-H4 expression in matched non-small cell lung cancer brain metastases and primary tumors},
  author={Zhen-ye Li and Xiang-heng Zhang and Yu Chen and Jian-gui Guo and K E Sai and Qun-ying Yang and Zhongping Chen and Yong-gao Mou},
  booktitle={OncoTargets and therapy},
  year={2013}
}
BACKGROUND B7-H4, a member of the inhibitory B7 family, is shown to have a profound inhibitory effect on the proliferation, activation, cytokine secretion, and development of cytotoxicity of T cells and may be involved in immune evasion in cancer patients. Although B7-H4 expression has been detected in non-small cell lung cancer (NSCLC), there are no published reports on the expression of B7-H4 in brain metastases from NSCLC. METHODS We examined the expression of B7-H4 by immunohistochemistry… CONTINUE READING
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