Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A.

Abstract

BACKGROUND Multiple endocrine neoplasia type 2A (MEN-2A) is characterized by medullary thyroid carcinoma in combination with pheochromocytoma and sometimes parathyroid adenoma. Missense mutations in the RET proto-oncogene are associated with MEN-2A. Their detection by DNA analysis allows the identification of carriers of the gene, in whom the risk of… (More)

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