Clinical role of diosmectite in the management of diarrhea

@article{Guarino2009ClinicalRO,
  title={Clinical role of diosmectite in the management of diarrhea},
  author={A. Guarino and A. L. Vecchio and M. Pirozzi},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2009},
  volume={5},
  pages={433 - 440}
}
Background: Diosmectite (DS), an antidiarrheal absorbent natural clay, was proposed for treatment of acute gastroenteritis and more recently considered for diarrhea within the functional bowel disorder syndrome. Objective: To review pharmacology efficacy, mechanisms of action and safety of DS. Methods: We consulted PubMed/Medline using the keywords of smectite and diarrhea or gastroenteritis, and reviewed most recent recommendations by scientific societies. Conclusions: Solid data show that DS… Expand
Copper-modified palygorskite is effective in preventing and treating diarrhea caused by Salmonella typhimurium
TLDR
It is suggested that copper-modified palygorskite (CM-Pal) may be an effective alternative to conventional antibiotics for the treatment and prevention of animal diarrhea caused by Salmonella. Expand
Pica in pregnancy: new ideas about an old condition.
  • S. Young
  • Biology, Medicine
  • Annual review of nutrition
  • 2010
TLDR
Current available data, although limited, best support the protection hypothesis as a cause of most types of pica, although some evidence suggests that pagophagy (ice consumption) may occur during iron deficiency. Expand
Copper/zinc-loaded montmorillonite influences intestinal integrity, the expression of genes associated with inflammation, TLR4–MyD88 and TGF-β1 signaling pathways in weaned pigs after LPS challenge
TLDR
Dietary Cu/Zn-Mt attenuated LPS-induced intestinal injury by alleviating intestinal inflammation, influencing TLR4-MyD88 and TGF-β1 signaling pathways in weaned piglets. Expand
Clay minerals in animal nutrition
Clay minerals are important in many facets of our society. Their properties such as structure and chemical composition, type of exchangeable ion and particle size determine their various uses. TheExpand
Effects of dietary supplementation with palygorskite on intestinal integrity in weaned piglets
The effects of dietary supplementation of palygorskite on intestinal integrity in weaned piglets were investigated in this study. Pigs weaned at 24 days of age (n = 27) were allocated to three groupsExpand
The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: A comparative study.
TLDR
Using various methods such as N2 adsorption and thermogravimetric analysis, the structure and texture of diosmectite and activated charcoal were attained and promethazine and imipramine were the most effectively adsorbed to diosMectite. Expand

References

SHOWING 1-10 OF 53 REFERENCES
Efficacy and tolerability of racecadotril in acute diarrhea in children.
TLDR
This study demonstrates the efficacy (up to 50% reduction in stool output) and tolerability of racecadotril as adjuvant therapy to oral rehydration solution in the treatment of severe diarrhea in infants and children. Expand
Comparative efficacy of dioctahedral smectite (Smecta) and a probiotic preparation in chronic functional diarrhoea.
  • Y. Yao-zong, L. Shi-rong, M. Delvaux
  • Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2004
TLDR
Dioctahedral smectite appeared in this study to be an effective and safe treatment of chronic functional diarrhoea, its effect starting during the first week of treatment and consisting in a decrease in the frequency of daily bowel movements and improvement of stool consistency. Expand
A controlled trial of bismuth subsalicylate in infants with acute watery diarrheal disease.
TLDR
Treatment with bismuth subsalicylate decreases the duration of diarrhea and is a safe and effective adjunct to oral rehydration therapy for infants and young children with acute watery diarrhea. Expand
Smectite in the Treatment of Acute Diarrhea: A Nationwide Randomized Controlled Study of the Italian Society of Pediatric Gastroenterology and Hepatology (SIGEP) in Collaboration With Primary Care Pediatricians
TLDR
Investigation in Italian children with acute diarrhea of mild to moderate severity found smectite reduces the duration of diarrhea and prevents a prolonged course, and may therefore consistently reduce the costs of gastroenteritis. Expand
The efficacy of bismuth subsalicylate in the treatment of acute diarrhoea and the prevention of persistent diarrhoea
TLDR
Unexpectedly, patients treated with BSS gained significantly more weight than those treated with placebo during the course of the study, and the toxicity of BSS was detected. Expand
Efficacy of dioctahedral smectite in treating patients of diarrhea‐predominant irritable bowel syndrome
TLDR
Dioctahedral smectite is natural adsorbent clay useful in treating acute diarrhea and efficacy on patients with diarrhea‐predominant irritable bowel syndrome in a phase III, 8‐week‐randomized, double‐blind, placebo‐controlled trial is determined. Expand
Racecadotril in the treatment of acute watery diarrhea in children.
TLDR
In young boys with acute watery diarrhea, racecadotril is an effective and safe treatment and the intake of oral rehydration solution was significantly lower in the racec Cadotril group than in the placebo group (P<0.001). Expand
The effect of two antidiarrhoeal drugs on the psychosocial adjustment to illness in chronic functional diarrhoea.
TLDR
Diosmectite has better effects on associated symptoms and some items of psychosocial adjustment to illness (distress, sexual activity and vocational environment) and loperamide is both potent drugs for chronic functional diarrhea. Expand
Anti‐inflammatory effect of diosmectite in hapten‐induced colitis in the rat
TLDR
Diosmectite has anti‐inflammatory activity administered as a post‐treatment to rats with chronic trinitrobenzene sulphonic acid colitis and is able to upregulate MUC2 mRNA levels in HT29‐MTX cells. Expand
Symptomatic treatment of diarrhea with bismuth subsalicylate among students attending a Mexican university.
TLDR
Subjective relief within 24 hr of therapy of the symptoms of diarrhea, nausea, and abdominal pain or cramps was reported with a significantly increased frequency in the bismuth subsalicylate group, and the most pronounced effect occurred in United States students with diarrhea who had recently arrived in Mexico. Expand
...
1
2
3
4
5
...