Clinical role of diosmectite in the management of diarrhea

  title={Clinical role of diosmectite in the management of diarrhea},
  author={Alfredo Guarino and Andrea Lo Vecchio and Maria Rosaria Pirozzi},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  pages={433 - 440}
Background: Diosmectite (DS), an antidiarrheal absorbent natural clay, was proposed for treatment of acute gastroenteritis and more recently considered for diarrhea within the functional bowel disorder syndrome. Objective: To review pharmacology efficacy, mechanisms of action and safety of DS. Methods: We consulted PubMed/Medline using the keywords of smectite and diarrhea or gastroenteritis, and reviewed most recent recommendations by scientific societies. Conclusions: Solid data show that DS… 
Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea
No microbiota-related physiological alterations are expected upon long-term treatment with diosmectite, and richness remained stable and no microbial species displayed a significant evolution.
Copper-modified palygorskite is effective in preventing and treating diarrhea caused by Salmonella typhimurium
It is suggested that copper-modified palygorskite (CM-Pal) may be an effective alternative to conventional antibiotics for the treatment and prevention of animal diarrhea caused by Salmonella.
Pica in pregnancy: new ideas about an old condition.
  • S. Young
  • Medicine
    Annual review of nutrition
  • 2010
Current available data, although limited, best support the protection hypothesis as a cause of most types of pica, although some evidence suggests that pagophagy (ice consumption) may occur during iron deficiency.
Copper/zinc-loaded montmorillonite influences intestinal integrity, the expression of genes associated with inflammation, TLR4–MyD88 and TGF-β1 signaling pathways in weaned pigs after LPS challenge
Dietary Cu/Zn-Mt attenuated LPS-induced intestinal injury by alleviating intestinal inflammation, influencing TLR4-MyD88 and TGF-β1 signaling pathways in weaned piglets.
Characteristics of Pica Behavior among Mothers around Lake Victoria, Kenya: A Cross-Sectional Study
The prevalence of pica among women on Mfangano Island, Kenya, underscores the need to uncover its dietary, environmental, and cultural etiologies.


Efficacy and tolerability of racecadotril in acute diarrhea in children.
This study demonstrates the efficacy (up to 50% reduction in stool output) and tolerability of racecadotril as adjuvant therapy to oral rehydration solution in the treatment of severe diarrhea in infants and children.
Comparative efficacy of dioctahedral smectite (Smecta) and a probiotic preparation in chronic functional diarrhoea.
  • Y. Yao-zong, L. Shi-rong, M. Delvaux
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2004
A controlled trial of bismuth subsalicylate in infants with acute watery diarrheal disease.
Treatment with bismuth subsalicylate decreases the duration of diarrhea and is a safe and effective adjunct to oral rehydration therapy for infants and young children with acute watery diarrhea.
Smectite in the Treatment of Acute Diarrhea: A Nationwide Randomized Controlled Study of the Italian Society of Pediatric Gastroenterology and Hepatology (SIGEP) in Collaboration With Primary Care Pediatricians
Investigation in Italian children with acute diarrhea of mild to moderate severity found smectite reduces the duration of diarrhea and prevents a prolonged course, and may therefore consistently reduce the costs of gastroenteritis.
The efficacy of bismuth subsalicylate in the treatment of acute diarrhoea and the prevention of persistent diarrhoea
Unexpectedly, patients treated with BSS gained significantly more weight than those treated with placebo during the course of the study, and the toxicity of BSS was detected.
Efficacy of dioctahedral smectite in treating patients of diarrhea‐predominant irritable bowel syndrome
Dioctahedral smectite is natural adsorbent clay useful in treating acute diarrhea and efficacy on patients with diarrhea‐predominant irritable bowel syndrome in a phase III, 8‐week‐randomized, double‐blind, placebo‐controlled trial is determined.
The effect of two antidiarrhoeal drugs on the psychosocial adjustment to illness in chronic functional diarrhoea.
Diosmectite has better effects on associated symptoms and some items of psychosocial adjustment to illness (distress, sexual activity and vocational environment) and loperamide is both potent drugs for chronic functional diarrhea.
Anti‐inflammatory effect of diosmectite in hapten‐induced colitis in the rat
Diosmectite has anti‐inflammatory activity administered as a post‐treatment to rats with chronic trinitrobenzene sulphonic acid colitis and is able to upregulate MUC2 mRNA levels in HT29‐MTX cells.
Control study of oral rehydration solution (ORS)/ORS + dioctahedral smectite in hospitalized Thai infants with acute secretory diarrhea.
It is concluded that smectite shortens the course of acute secretory diarrhea in Thai infants and may reduce the occurrence of prolonged diarrhea, and dioctahedral Smectite was found to be safe in children aged 1 to 24 months.