Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis.

  title={Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis.},
  author={P. Anagnostis and V. Athyros and K. Tziomalos and A. Karagiannis and D. Mikhailidis},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={94 8},
  • P. Anagnostis, V. Athyros, +2 authors D. Mikhailidis
  • Published 2009
  • Medicine
  • The Journal of clinical endocrinology and metabolism
  • CONTEXT The metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increase the risk for type 2 diabetes mellitus and vascular disease. The common characteristics of MetS and hypercortisolemic conditions such as Cushing's syndrome (CS) suggest that the pathogenesis of MetS and central obesity might involve prolonged and excessive exposure to glucocorticoids. The present review summarizes the evidence on the potential role of cortisol in the pathogenesis of MetS and discusses new… CONTINUE READING
    525 Citations

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