Clinical review: Pseudohypoparathyroidism: diagnosis and treatment.

  title={Clinical review: Pseudohypoparathyroidism: diagnosis and treatment.},
  author={Giovanna Mantovani},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={96 10},
CONTEXT The term pseudohypoparathyroidism (PHP) indicates a group of heterogeneous disorders whose common feature is represented by impaired signaling of various hormones (primarily PTH) that activate cAMP-dependent pathways via Gsα protein. The two main subtypes of PHP, PHP type Ia, and Ib (PHP-Ia, PHP-Ib) are caused by molecular alterations within or upstream of the imprinted GNAS gene, which encodes Gsα and other translated and untranslated products. EVIDENCE ACQUISITION A PubMed search… CONTINUE READING


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