Clinical relevance of vascular endothelial growth factor receptors 1 and 2 in acute myeloid leukaemia and myelodysplastic syndrome.

@article{Verstovsek2002ClinicalRO,
  title={Clinical relevance of vascular endothelial growth factor receptors 1 and 2 in acute myeloid leukaemia and myelodysplastic syndrome.},
  author={Srdan Verstovsek and Elihu Estey and Taghi Manshouri and Francis J Giles and Jorge E. Cortes and Miloslav E Beran and Anna Rogers and Michael J Keating and Hagop M Kantarjian and Maher Albitar},
  journal={British journal of haematology},
  year={2002},
  volume={118 1},
  pages={151-6}
}
We have previously reported that high levels of cellular vascular endothelial growth factor (VEGF) protein correlated with short survival of patients with acute myeloid leukaemia (AML). As VEGF exerts its effects via two receptors, VEGF receptor 1 (VEGFR-1) and VEGFR-2, we evaluated the significance of VEGFR-1 and VEGFR-2 protein levels in AML and myelodysplastic syndrome (MDS), and their relationship to VEGF protein levels. Western blot analysis and radioimmunoassay confirmed and quantified… CONTINUE READING

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