Clinical relevance of the neurotrophins and their receptors.

  title={Clinical relevance of the neurotrophins and their receptors.},
  author={S. Allen and D. Dawbarn},
  journal={Clinical science},
  volume={110 2},
  • S. Allen, D. Dawbarn
  • Published 2006
  • Medicine
  • Clinical science
  • The neurotrophins are growth factors required by discrete neuronal cell types for survival and maintenance, with a broad range of activities in the central and peripheral nervous system in the developing and adult mammal. This review examines their role in diverse disease states, including Alzheimer's disease, depression, pain and asthma. In addition, the role of BDNF (brain-derived neurotrophic factor) in synaptic plasticity and memory formation is discussed. Unlike the other neurotrophins… CONTINUE READING
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