Clinical relevance of the ESKAPE pathogens

  title={Clinical relevance of the ESKAPE pathogens},
  author={Jack Norman Pendleton and Sean P. Gorman and Brendan F. Gilmore},
  journal={Expert Review of Anti-infective Therapy},
  pages={297 - 308}
In recent years, the Infectious Diseases Society of America has highlighted a faction of antibiotic-resistant bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) – acronymically dubbed ‘the ESKAPE pathogens’ – capable of ‘escaping’ the biocidal action of antibiotics and mutually representing new paradigms in pathogenesis, transmission and resistance. This review aims to consolidate clinically… 

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    Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive
  • 2017
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A second clinical infection due to a resistant MRSA was reported, but unlike the earlier case this was shown to have developed from a susceptible isolate during treatment, and linezolid susceptibility was determined.

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Klebsiella pathogenicity factors such as capsules or lipopolysaccharides are presently considered to be promising candidates for vaccination efforts that may serve as immunological infection control measures.

Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremia.

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  • D. Livermore
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    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2002
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Daptomycin at high concentration retained bactericidal activity against resistant isolates and resistance in patients with osteomyelitis due to methicillin-resistant S. aureus.

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    The Journal of infectious diseases
  • 2008
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