Clinical relevance of flow cytometric immunophenotyping of the cerebrospinal fluid in patients with diffuse large B-cell lymphoma.

@article{Alvarez2012ClinicalRO,
  title={Clinical relevance of flow cytometric immunophenotyping of the cerebrospinal fluid in patients with diffuse large B-cell lymphoma.},
  author={Rodr{\'i}guez Alvarez and Jehan M Dupuis and Anne Plonquet and Christophe Christov and Christiane Copie-Bergman and François Hemery and Isabelle Gaillard and Taoufik El Gnaoui and Fr{\'e}d{\'e}rique Kuhnowski and Manel Bedoui and Karim Belhadj and P. Brugi{\`e}res and Corinne Haioun},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2012},
  volume={23 5},
  pages={1274-9}
}
BACKGROUND Central nervous system (CNS) relapse is an uncommon but dramatic complication of diffuse large B-cell lymphoma (DLBCL). Several studies have demonstrated the superiority of cerebrospinal fluid (CSF) flow cytometry (FCM), as compared with conventional cytology (CC), in detecting occult leptomeningeal disease. The clinical relevance of a positive FCM still has to be clarified. PATIENTS AND METHODS We analyzed CSF from 114 DLBCL patients at diagnosis (n = 95) or at relapse (n = 19) by… CONTINUE READING
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