Clinical relevance of erbB-1 and -2 oncogenes in oral carcinomas.

@article{Werkmeister2000ClinicalRO,
  title={Clinical relevance of erbB-1 and -2 oncogenes in oral carcinomas.},
  author={Richard Werkmeister and B. van der Brandt and Ulrich Joos},
  journal={Oral oncology},
  year={2000},
  volume={36 1},
  pages={
          100-5
        }
}
To gain a better understanding of molecular changes in oral squamous cell carcinomas, we tested fresh tumour specimens from 110 patients for erbB-1 and -2 oncogene aberrations using the competitive differential polymerase chain reaction. The significance of established tumour characteristics such as TNM stage, differentiation and oncogene aberrations for tumour progression were analyzed. ErbB-2 amplification with a gene copy number > 1.6 in tumour tissue and erbB-1 deletion with a gene copy… CONTINUE READING

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