Clinical relevance of detection of lymphovascular invasion in primary melanoma using endothelial markers D2-40 and CD34.

@article{Rose2011ClinicalRO,
  title={Clinical relevance of detection of lymphovascular invasion in primary melanoma using endothelial markers D2-40 and CD34.},
  author={Amy E Rose and Paul J. Christos and Dan Lackaye and Richard L. Shapiro and Russell Berman and Madhu Mazumdar and Hideko Kamino and Iman Osman and Farbod Darvishian},
  journal={The American journal of surgical pathology},
  year={2011},
  volume={35 10},
  pages={1441-9}
}
Immunohistochemistry (IHC) using endothelial markers may facilitate the detection of lymphovascular invasion (LVI) in primary melanoma; however, the clinical implications of enhanced detection are unknown. We evaluated whether the use of lymphatic endothelial marker D2-40 and panvascular marker CD34 increases LVI positivity relative to routine histology alone and then evaluated the prognostic relevance of LVI detected using these markers in terms of disease-free (DFS) and overall survival (OS… CONTINUE READING