Clinical relevance of cytogenetics in myelodysplastic syndromes.

  title={Clinical relevance of cytogenetics in myelodysplastic syndromes.},
  author={P. Bernasconi and Marina Boni and Paola Maria Cavigliano and Silvia Calatroni and Ilaria Giardini and Barbara Rocca and Rita Zappatore and Irene Dambruoso and Marilena Caresana},
  journal={Annals of the New York Academy of Sciences},
Myelodysplastic syndromes (MDS) are a group of heterogeneous stem cell disorders with different clinical behaviors and outcomes. Conventional cytogenetics (CC) studies have demonstrated that the majority of MDS patients harbor clonal chromosome defects. The probability of discovering a chromosomal abnormality has been increased by fluorescence in situ hybridization (FISH), which has revealed that about 15% of patients with a normal chromosome pattern on CC may instead present cryptic defects… CONTINUE READING
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