Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine.

@article{Zivadinov2016ClinicalRO,
  title={Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine.},
  author={Robert Zivadinov and D Jakimovski and Sirin Gandhi and Rahil Ahmed and Michael G. Dwyer and D. Hor{\'a}kov{\'a} and Bianca Weinstock-Guttman and R H B Benedict and M Vaneckova and Michael Harry Barnett and Niels P Bergsland},
  journal={Expert review of neurotherapeutics},
  year={2016},
  volume={16 7},
  pages={777-93}
}
INTRODUCTION Brain atrophy measurement in multiple sclerosis (MS) has become an important outcome for determining patients at risk for developing physical and cognitive disability. AREAS COVERED In this article, we discuss the methodological issues related to using this MRI metric routinely, in a clinical setting. Understanding trajectories of annualized whole brain, gray and white matter, thalamic volume loss, and enlargement of ventricular space in specific MS phenotypes is becoming… CONTINUE READING

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