Clinical relevance of age-related immune dysfunction.

@article{Castle2000ClinicalRO,
  title={Clinical relevance of age-related immune dysfunction.},
  author={Steven Charles Castle},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2000},
  volume={31 2},
  pages={
          578-85
        }
}
  • S. Castle
  • Published 1 August 2000
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Immunosenescence is the state of dysregulated immune function that contributes to the increased susceptibility to infection of the elderly. Extensive studies of inbred laboratory animals and very healthy elderly humans have identified changes in immunity; these studies have identified limited phenotypic and functional changes in the T cell component of adaptive immunity. However, no compelling scientific evidence has shown that these changes have direct relevance to the common infections seen… Expand
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