Clinical relevance of P-glycoprotein in drug therapy.

@article{Lin2003ClinicalRO,
  title={Clinical relevance of P-glycoprotein in drug therapy.},
  author={Jiunn Huei Lin and Masayo Yamazaki},
  journal={Drug metabolism reviews},
  year={2003},
  volume={35 4},
  pages={417-54}
}
The drug efflux transporter P-glycoprotein (P-gp) is known to confer multidrug resistance in cancer chemotherapy. The P-gp is highly expressed in many types of tumor cells, as well as many normal tissues, including the apical surface of intestinal epithelial cells, and the luminal surface of capillary endothelial cells in the brain. Because of its expression and localization, it has been suggested that P-gp plays an important role in cancer chemotherapy, intestinal absorption, and brain uptake… CONTINUE READING

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