Clinical relevance and management of drug-related QT interval prolongation.

  title={Clinical relevance and management of drug-related QT interval prolongation.},
  author={Michael A. Crouch and Lynn Limon and Angela Turner Cassano},
  volume={23 7},
Much attention recently has focused on drugs that prolong the QT interval, potentially leading to fatal cardiac dysrhythmias (e.g., torsade de pointes). We provide a detailed review of the published evidence that supports or does not support an association between drugs and their risk of QT prolongation. The mechanism of drug-induced QT prolongation is reviewed briefly, followed by an extensive evaluation of drugs associated with QT prolongation, torsade de pointes, or both. Drugs associated… CONTINUE READING


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Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques • 2016
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