[Clinical problems in medical mycology: problem number 46].


A 49 year old-man, without known previous diseases, who suffered an acute lung infection, is presented. He was a smoker and belonged to a high socioeconomic class. He suddenly presented high fever, dry cough and legs' pain. Thorax X-ray and CT scan showed two excavated pneumonic infiltrates in the lower part of the right lung. He was treated with antibacterial antibiotics without clinical response. A transparietal fine needle lung biopsy was performed and the histopathology and cytological studies revealed an epithelioid granuloma with capsulated yeasts. Cryptococcus neoformans antigenemia was positive 1/128, and brain MR, as well as CSF studies, allowed to rule out a central nervous system compromise. The patient was successfully treated with itraconazole by oral route at a daily dose of 400mg during 6 months. Post-treatment thorax CT scan showed a thin walled lung cavity as a sequela.

DOI: 10.1016/j.riam.2013.01.004

Cite this paper

@article{Negroni2014ClinicalPI, title={[Clinical problems in medical mycology: problem number 46].}, author={Ricardo Negroni and Alicia Irene Arechavala and Gabriela Mar{\'i}a Santiso and Pablo E Bonveh{\'i}}, journal={Revista iberoamericana de micología}, year={2014}, volume={31 3}, pages={207-9} }