Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment

@article{Fleisher2007ClinicalPO,
  title={Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment},
  author={A. Fleisher and B. Sowell and C. Taylor and A. Gamst and R. Petersen and L. Thal},
  journal={Neurology},
  year={2007},
  volume={68},
  pages={1588 - 1595}
}
Objective: To investigate the neurocognitive measures that best predict progression from amnestic mild cognitive impairment (aMCI) to Alzheimer disease (AD). Methods: We evaluated 539 participants with aMCI from the Alzheimer's Disease Cooperative Study clinical drug trial of donepezil, vitamin E, or placebo. During the study period of 36 months, 212 aMCI participants progressed to AD. Using progression from aMCI to AD within 36 months as the dependent variable, a generalized linear model was… Expand
Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment
TLDR
In moderate stages of amnestic mild cognitive impairment, common cognitive tests provide better predictive accuracy than measures of whole brain, ventricular, entorhinal cortex, or hippocampal volumes for assessing progression to Alzheimer disease. Expand
Higher Working Memory Predicts Slower Functional Decline in Autopsy-Confirmed Alzheimer's Disease
TLDR
Preservation of working memory, but not episodic memory, in the mild cognitive impairment and early dementia stages of AD relates to slower rate of functional decline. Expand
The Importance of Alzheimer Disease Assessment Scale-cognitive Part in Predicting Progress for Amnestic Mild Cognitive Impairment to Alzheimer Disease
TLDR
ADAS-Cog subscale is a useful and brief cognitive assessment tool to screen aMCI participants converting to AD within 1 year, and shows a good performance in predicting conversion from a MCI to AD. Expand
Predicting progression to Alzheimer’s disease in subjects with amnestic mild cognitive impairment using performance on recall and recognition tests
TLDR
Word list recognition correctly classified group membership with good overall accuracy, which was higher compared to the classification of converter and stable a-MCIs provided by free recall, could be a useful diagnostic tool for predicting progression to AD dementia from the prodromal stage. Expand
Word-List Intrusion Errors Predict Progression to Mild Cognitive Impairment
TLDR
Intrusion errors appear to reflect subtle change and inefficiencies in cognition that precede impairment detected by neuropsychological total scores in those at risk for progression to MCI. Expand
One-year Outcome of Shanghai Mild Cognitive Impairment Cohort Study.
TLDR
Early detection of AD and potential selection for clinical trial design should utilize the rt. Expand
Detection of early Alzheimer's disease in MCI patients by the combination of MMSE and an episodic memory test
TLDR
Pr-AD might be distinguished from S-MCI at baseline using the combination of MMSE and CVLT-LDTR, which are relatively brief and may be readily completed in non-specialist clinical settings. Expand
Predictors of rate of cognitive decline in patients with amnestic mild cognitive impairment.
TLDR
Identifying potential predictors of rate of decline from amnestic MCI to AD could be clinically meaningful for prognostic purposes, understanding risk and protective factors, as well as guiding future treatments and clinical trials that could aim to target and delay progression among those patients who are vulnerable to more quickly convert to AD. Expand
Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?
TLDR
Clinical features alone were insufficient to predict development of dementia, and patients presenting with amnestic MCI insufficient for the diagnosis of dementia are at high risk of developing dementia on follow-up. Expand
Neuropsychological predictors of conversion from mild cognitive impairment to Alzheimer's disease.
TLDR
Results of this review suggest that measures of delayed recall are the best neuropsychological predictors of conversion from MCI to AD; memory tests providing controlled encoding and cued recall are not necessarily better predictors than free recall tests; stringent cut-off points are necessary to increase the specificity of these predictors. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
Amnestic mild cognitive impairment: Diagnostic outcomes and clinical prediction over a two-year time period
TLDR
It is demonstrated that commonly administered neuropsychological tests identify persons with MCI at baseline who are at risk for conversion to AD within 1–2 years and such methods could aid in identifying MCI patients who might benefit from early treatment and providing prognostic information to patients. Expand
Mild cognitive impairment: clinical characterization and outcome.
TLDR
Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions. Expand
Mild cognitive impairment in different functional domains and incident Alzheimer’s disease
TLDR
Among persons with mild cognitive impairment, episodic memory impairment is associated with a substantial and persistent elevation in risk of developing AD compared to impairment in other cognitive systems. Expand
Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals.
TLDR
Patients with mild cognitive impairment can be clinically defined, many members of this group progress to Alzheimer's disease, and APOE epsilon 4 allele status appears to be a strong predictor of clinical progression. Expand
Attention and executive control predict Alzheimer disease in late life: results from the Berlin Aging Study (BASE).
  • M. Rapp, F. Reischies
  • Psychology, Medicine
  • The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2005
TLDR
Tailored models of attention and executive function in the preclinical phase of AD in old age support theoretical models of neuropsychological processes before AD onset and significantly predicted incident AD over and above age, gender, and education. Expand
Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment.
TLDR
APOE epsilon4 carrier status was associated with conversion to AD in older outpatients after controlling for known demographic and clinical risk factors, and APOE ePSilon4 homozygosity was associatedwith increased risk of conversion toAD. Expand
Prediction of probable Alzheimer's disease in memory-impaired patients
TLDR
It is demonstrated that probable AD can be predicted with a high degree of accuracy and with a relatively brief battery of neuropsychological tests. Expand
Neuropsychological Prediction of Decline to Dementia in Nondemented Elderly
TLDR
A subanalysis of the high-risk GDS 3 subgroup indicated that cut scores from the paragraph test distinguished nondecliners from decliners (overall accuracies 87%-91%), implying that this assessment may accurately predict future cognitive status in elderly with mild cognitive impairment. Expand
Diagnostic accuracy of the Preclinical AD Scale (PAS) in cognitively mildly impaired subjects
TLDR
The Preclinical AD Scale is a useful scale to identify subjects with preclinical AD who will become demented during the next 2 or 5 years and step-wise scoring of the PAS can reduce the number of elaborate or expensive diagnostic procedures considerably. Expand
Executive function deficits in early Alzheimer's disease and their relations with episodic memory.
TLDR
The comparison with 17 normal controls shows that very mild AD patients had deficits on visuospatial short-term memory, episodic memory, flexibility and self-monitoring abilities, concept formation and reasoning, and the mildAD patients showed additional deficits on the Similarities test. Expand
...
1
2
3
4
5
...