Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models.

@article{VoskoglouNomikos2003ClinicalPV,
  title={Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models.},
  author={Theodora Voskoglou-Nomikos and Joseph L. Pater and Lesley Seymour},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 11},
  pages={4227-39}
}
PURPOSE We looked at the value of three preclinical cancer models, the in vitro human cell line, the human xenograft, and the murine allograft, to examine whether they are reliable in predicting clinical utility. EXPERIMENTAL DESIGN Thirty-one cytotoxic cancer drugs were selected. Literature was searched for drug activity in Phase II trials, human… CONTINUE READING
  • Blog articles referencing this paper

  • Presentations referencing similar topics