Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult.

@article{Jacobi2002ClinicalPG,
  title={Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult.},
  author={Judith Jacobi and Gilles L Fraser and Douglas B. Coursin and Richard R. Riker and Dorrie K. Fontaine and Eric T Wittbrodt and Donald B. Chalfin and Michael F Masica and H. Scott Bjerke and William M. Coplin and David W. Crippen and Barry D. Fuchs and Ruth M Kelleher and Paul Ellis Marik and Stanley A. Nasraway and Michael J. Murray and William T. Peruzzi and Philip D. Lumb},
  journal={Critical care medicine},
  year={2002},
  volume={30 1},
  pages={
          119-41
        }
}
Judith Jacobi, PharmD, FCCM, BCPS; Gilles L. Fraser, PharmD, FCCM; Douglas B. Coursin, MD; Richard R. Riker, MD; Dorrie Fontaine, RN, DNSc, FAAN; Eric T. Wittbrodt, PharmD; Donald B. Chalfin, MD, MS, FCCM; Michael F. Masica, MD, MPH; H. Scott Bjerke, MD; William M. Coplin, MD; David W. Crippen, MD, FCCM; Barry D. Fuchs, MD; Ruth M. Kelleher, RN; Paul E. Marik, MDBCh, FCCM; Stanley A. Nasraway, Jr, MD, FCCM; Michael J. Murray, MD, PhD, FCCM; William T. Peruzzi, MD, FCCM; Philip D. Lumb, MB, BS… Expand
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National Survey of the Use of Sedating Drugs, Neuromuscular Blocking Agents, and Reversal Agents in the Intensive Care Unit
The objectives of this study were to describe the sedative, neuromuscular blocking agents (NMBA) and reversal agents utilized in adult intensive care units across the United States and determine theExpand
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Pain management principles in the critically ill.
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References

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Sedation, analgesia, and neuromuscular blockade of the critically ill adult: revised clinical practice guidelines for 2002.
The critically ill and injured patient is invariably anxious, confused, uncomfortable, and in pain from immobility, wounds, and indwelling tubes and is generally distressed by the adverse environs ofExpand
Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: an executive summary. Society of Critical Care Medicine.
TLDR
A consensus of experts provided six recommendations with supporting data for intravenous analgesia and sedation in the ICU setting, and an executive summary was prepared for publication by the ACCM Board of Regents and this executive summary selectively presents supporting information. Expand
Sedatives, Analgesics, and Paralytics in the Icu
TLDR
Assessing sedative/pain/paralytic drug use patterns including dosage, route, selection, and combination therapy by collecting actual drug administration data from multiple centers suggested a preference for opiate and benzodiazepine therapy. Expand
Optimal intravenous dosing strategies for sedatives and analgesics in the intensive care unit.
TLDR
There is a high degree of interpatient variability among critically ill patients, and medication dosing must be tailored to individual patients' needs, so the best ways to achieve and maintain optimal levels of sedation and analgesia while minimizing the risk of oversedation and side effects are to initiate sedation in an incremental fashion and gradually increase the infusion rate. Expand
Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: a prospective, randomized comparison.
TLDR
Lorazepam appears to be a cost-effective choice for sedation; however, oversedation may be problematic and midazolam is the most titratable drug in the population, avoiding excessive oversedations or undersedation. Expand
Patterns of prescribing and administering drugs for agitation and pain in patients in a surgical intensive care unit
TLDR
A wide variety of sedatives and analgesics are frequently used in surgical ICU patients, and these agents are often ordered on an “as-needed” basis using a range of doses, sometimes without adequate directions about the indication for their use. Expand
Pharmacoeconomic impact of rational use guidelines on the provision of analgesia, sedation, and neuromuscular blockade in critical care
TLDR
Rational use guidelines resulted in safe, cost-effective improvements in the provision of continuous analgesia, sedation, and neuromuscular blockade to critically ill patients requiring ventilator management when compared with similar factors in baseline prescribing strategies. Expand
The use of analgesics and sedatives in critically ill patients: physicians' orders versus medications administered.
TLDR
A need exists to educate Physicians as to what patients actually receive for sedation and analgesia and at the same time improve the dialogue between nurses and physicians as toWhat patients actually require. Expand
Pharmacokinetics and Pharmacodynamics of Sedatives and Analgesics in the Treatment of Agitated Critically Ill Patients
TLDR
The pharmacokinetics and pharmacodynamics of sedatives and analgesics are significantly altered in the critically ill, and specific monitoring tools may assist clinicians in the regulation of infusions of sedative and analgesic agents. Expand
Lorazepam and midazolam in the intensive care unit: a randomized, prospective, multicenter study of hemodynamics, oxygen transport, efficacy, and cost.
TLDR
Sedation and anxiolysis with lorazepam and midazolam in critically ill patients is safe and clinically effective and Hemodynamic and oxygen transport variables are similarly affected by both drugs. Expand
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