Working with DS patients in primary, specialty, and acute care health settings has always been a demanding task for the busy practitioner. The associated medical conditions, developmental demands, and educational demands makes it challenging for pediatric care providers to address all the specific details for each age group. The purpose of this two-part Practice Guideline is to streamline this process. Part One has summarized the care of the patient with DS until the age of 1 year. Part Two will focus on care from the child's first birthday until he or she transitions to adulthood.