Clinical practice and implications of recent diabetes trials

@article{Webster2011ClinicalPA,
  title={Clinical practice and implications of recent diabetes trials},
  author={Mark Wi Webster},
  journal={Current Opinion in Cardiology},
  year={2011},
  volume={26},
  pages={288–293}
}
  • M. Webster
  • Published 1 July 2011
  • Medicine
  • Current Opinion in Cardiology
Purpose of review Diabetes is an increasingly prevalent risk factor for coronary and other vascular disease. Recent trials in patients with diabetes have examined the effects of intensive glycemic control on cardiovascular outcomes, and treatment of common concomitant risk factors, in particular hypertension and dyslipidemia. Optimal revascularization strategies have also been examined. Recent findings Intensive glycemic control has a beneficial effect on microvascular but not macrovascular… 
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13 Citations
Background Citations
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References

SHOWING 1-10 OF 48 REFERENCES

A randomized trial of therapies for type 2 diabetes and coronary artery disease.

Overall, there was no significant difference in the rates of death and major cardiovascular events between patients undergoing prompt revascularization and those undergoing medical therapy or between strategies of insulin sensitization and insulin provision.

Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease.

Tight control of systolic BP among patients with diabetes and CAD was not associated with improved cardiovascular outcomes compared with usual control, and little difference existed between those withUsually control and those with tight control.

Cardiovascular events during differing hypertension therapies in patients with diabetes.

Health Status After Treatment for Coronary Artery Disease and Type 2 Diabetes Mellitus in the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial

Background— Health status is a key outcome for comparing treatments, particularly when mortality does not differ significantly. Methods and Results— Bypass Angioplasty Revascularization Investigation…

Effect of Rosiglitazone on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease: The Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in Diabetes Patients With Cardiovascular History Trial

Rosiglitazone did not significantly decrease the primary end point of progression of coronary atherosclerosis more than glipizide in patients with type 2 diabetes mellitus and coronary Atherosclerosis.

Aspirin for Primary Prevention of Cardiovascular Events in People With Diabetes: A Position Statement of the American Diabetes Association, a Scientific Statement of the American Heart Association, and an Expert Consensus Document of the American College of Cardiology Foundation

Aspirin has been shown to be effective in reducing cardiovascular morbidity and mortality in high-risk patients with myocardial infarction (MI) or stroke (secondary prevention), and its net benefit among patients with no previous cardiovascular events is more controversial.

Effects of combination lipid therapy in type 2 diabetes mellitus.

The routine use of combination therapy with fenofibrate and simvastatin to reduce cardiovascular risk in the majority of high-risk patients with type 2 diabetes does not support the routine use.

Long-term effects of intensive glucose lowering on cardiovascular outcomes.

The use of intensive therapy for 3.7 years to target a glycated hemoglobin level below 6% reduced 5-year nonfatal myocardial infarctions but increased 5- year mortality, and such a strategy cannot be recommended for high-risk patients with advanced type 2 diabetes.

Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis.

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.

A strategy of intensive glucose control, involving gliclazide (modified release) and other drugs as required, that lowered the glycated hemoglobin value to 6.5% yielded a 10% relative reduction in the combined outcome of major macrovascular and microvascular events, primarily as a consequence of a 21%relative reduction in nephropathy.