Clinical pharmacology of two specific bradycardiac agents.

  title={Clinical pharmacology of two specific bradycardiac agents.},
  author={Hans-Joachim Franke and C. A. P. F. Su and Karl Schumacher and Michael K Seiberling},
  journal={European heart journal},
  volume={8 Suppl L},
The effect of two i.v.-infusion regimens of falipamil on atropine-induced changes of heart rate and the effect of ULFS 49 Cl in 3 different oral doses during a 7-day medication period were studied in volunteers. Both studies were double-blind, randomized and placebo controlled. Under placebo, low doses of atropine caused a 16% reduction in heart rate, a 1 mg cumulative dose increased heart rate by 23%. 100 mg falipamil was followed by a 9% reduction in heart rate. Low doses of atropine enhanced… CONTINUE READING