Clinical pharmacology of topiramate in migraine prevention

  title={Clinical pharmacology of topiramate in migraine prevention},
  author={Anna Ferrari and Ilaria Tiraferri and Laura Neri and Emilio Sternieri},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  pages={1169 - 1181}
Introduction: Migraine is a widespread disorder. Migraine patients experience worse health-related quality of life than the general population. The availability of effective and tolerable treatments for this disorder is an important medical need. This narrative review focuses on the clinical pharmacology of topiramate, an antiepileptic drug that was approved for the prophylaxis of migraine where it should act as a neuromodulator. Areas covered: A PubMed database search (from 2000 to 24 January… Expand
Topiramate: Comprehensive profile.
The weight loss observed with the use of topiramate in obese, epileptic patients, afforded the approval of this drug as an anti-obesity medication and this action is thought to be based on the selective inhibition of mitochondrial carbonic anhydrase isoforms. Expand
Actualización en la prevención y tratamiento de la migraña
Advances made in the knowledge of the pathophysiology of migraines, new treatment options were developed and these new options include onabotulinum toxin A and topiramate. Expand
Evaluating the Phase II drugs currently under investigation for diabetic neuropathy
It is hoped that drugs which improve vascular blood flow, induce neural regeneration, reduce hyperglycemia, oxidative stress and inflammation can be more effective for the overall treatment of painful DN. Expand
Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway
Treatment of POCD rats with TPM could suppress neuronal apoptosis in the hippocampus tissues, and the neuroprotective effects of TPM may relate with the regulation of tumor necrosis factor (TNF) signaling pathway. Expand
Long-lasting recognition memory impairment and alterations in brain levels of cytokines and BDNF induced by maternal deprivation: effects of valproic acid and topiramate
Exposure to stressful events early in life may have permanent deleterious consequences on nervous sys- tem function and increase the susceptibility to psychiatric conditions later in life. MaternalExpand
The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system
The present study aimed at investigating the mechanism of the insulin‐sensitizing effect of topiramate both in vivo and in vitro. Expand
Long-lasting recognition memory impairment and alterations in brain levels of cytokines and BDNF induced by maternal deprivation: effects of valproic acid and topiramate
Investigation of the effects of maternal separation on the levels of IL-10 and TNF-α, and BDNF in the hippocampus and prefrontal cortex of adult rats indicated that, in addition to inducing memory deficits, maternal deprivation increased the levels and decreased hippocampal levels of BDNF, in adult life. Expand
Synthesis and Human Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating Mono-, Bi- and Tricyclic Imide Moieties
New derivatives were synthesised by reaction of amino-containing aromatic sulphonamides with mono-, bi-, and tricyclic anhydrides with the help of molecular docking studies and the structure–activity relationships (SAR) are rationalised. Expand


Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
Topiramate is an antipileptic drug with a complex mode of action which has proven its efficacy and safety in the prophylactic treatment of episodic migraine in a number of randomized controlled clinical trials and is generally well tolerated by patients. Expand
Practical Use of Topiramate for Migraine Prevention
“real‐world” approaches to using topiramate as a migraine‐preventive therapy will enable clinicians to maximize the effectiveness while minimizing the side effects associated with this preventive agent. Expand
Chronic migraine prevention with topiramate
Topiramate is effective in CM prophylaxis and the most common side effects found were weight loss, paraesthesias, nausea, cognitive dysfunction, fatigue, somnolence, insomnia and depression. Expand
Newer antiepileptic drugs: possible uses in the treatment of neuropathic pain and migraine.
There is currently insufficient evidence to determine whether the newer AEDs in the treatment of neuropathic pain and migraine have equal or superior efficacy relative to proven pharmacotherapies. Expand
New drugs in migraine treatment and prophylaxis: telcagepant and topiramate
Data suggest that topiramate could aid reversion of chronic migraine to episodic migraine, and Telcagepant might provide hope for those who have a poor response to, or are unable to use, older drugs. Expand
Subcutaneous Histamine versus Topiramate in Migraine Prophylaxis: A Double-Blind Study
Evidence of the efficacy of subcutaneous applied histamine and orally administered topiramate in migraine prophylaxis is provided, indicating that subcutaneously applied histamines may represent a novel and effective therapeutic alternative in resistant migraine patients. Expand
Topiramate in migraine prophylaxis: a randomised double-blind versus placebo study
TPM has thus proven its efficacy and tolerability in the prophylaxis of migraine and a significant downward trend in the number of days of disability over the 16-week period of therapy. Expand
[Topiramate or flunarizine in the preventive treatment of migraine. A comparative study of two series of cases].
Both drugs showed a high degree of effectiveness when used as the preferred drug in the preventive treatment of migraine and topiramate offered better results as far as effectiveness is concerned, but also more side effects, none of which were serious. Expand
Topiramate for Migraine Prevention in a Naturalistic Setting: Results From an Open Label, Flexible Dose Study
Data on patient outcomes with preventive medication derive mostly from specialized academic centers, which contrasts with normal clinical practice where the majority of patients are treated outside tertiary care centers. Expand
Topiramate in the Preventive Treatment of Episodic Migraine: A Combined Analysis From Pilot, Double-Blind, Placebo-Controlled Trials
Topiramate is effective and well tolerated in the preventive treatment of migraine headaches, and two single-center, double-blind, placebo-controlled studies suggest that it is. Expand