Clinical pharmacology of topiramate: a review.

  title={Clinical pharmacology of topiramate: a review.},
  author={William R. Garnett},
  volume={41 Suppl 1},
Clinical success with an antiepileptic drug (AED) depends primarily on its efficacy and tolerability. Clinicians also need to have a basic understanding of an AED's pharmacokinetic characteristics, particularly those affecting the potential for drug interactions such as hepatic enzyme inhibition or induction and protein-binding displacement. Successful treatment may be complicated by pharmacokinetic characteristics such as a short half-life, nonlinear kinetics, and active metabolites… CONTINUE READING

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