Clinical pharmacology of selective COX-2 inhibitors.

  title={Clinical pharmacology of selective COX-2 inhibitors.},
  author={Marta L Capone and Stefania Tacconelli and Maria Gina Sciulli and Paola Patrignani},
  journal={International journal of immunopathology and pharmacology},
  volume={16 2 Suppl},
The discovery of cyclooxygenase (COX)-2 has provided the rationale for the development of a new class of nonsteroidal antiinflammatory drugs (NSAIDs), the selective COX-2 inhibitors (denominated coxibs), with the aim of reducing the gastrointestinal (GI) toxicity associated with the administration of NSAIDs by virtue of COX-1 sparing. Rofecoxib and celecoxib are the first selective COX-2 inhibitors approved by the FDA and EMEA for the treatment of rheumatoid arthritis (RA), osteoarthritis (OA… CONTINUE READING
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