Clinical pharmacology of recombinant human luteinizing hormone: Part II. Bioavailability of recombinant human luteinizing hormone assessed with an immunoassay and an in vitro bioassay.


OBJECTIVE To assess the single-dose pharmacokinetics of a recombinant human LH preparation administered by the i.v., i.m., and s.c. route. DESIGN Prospective, randomized cross-over study. SETTING Phase I clinical research environment. PATIENT(S) Twelve healthy pituitary down-regulated females. INTERVENTION(S) Subjects received single i.v., i.m., and… (More)

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