Clinical pharmacology of proton pump inhibitors: what the practising physician needs to know.

@article{Robinson2003ClinicalPO,
  title={Clinical pharmacology of proton pump inhibitors: what the practising physician needs to know.},
  author={M. G. Robinson and John Louis Horn},
  journal={Drugs},
  year={2003},
  volume={63 24},
  pages={2739-54}
}
Proton pump inhibitors (PPIs) [omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole] are widely utilised for the treatment of gastro-oesophageal reflux disease, as well as other acid-related disorders. All PPIs suppress gastric acid secretion by blocking the gastric acid pump, H(+)/K(+)-adenosine triphosphatase (ATPase), but the physicochemical properties of these drugs result in variations in the degree of acid suppression, as well as the speed of onset of acid inhibition. Such… CONTINUE READING
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