Clinical pharmacology of methadone for pain

@article{Fredheim2008ClinicalPO,
  title={Clinical pharmacology of methadone for pain},
  author={Olav Magnus Fredheim and Kristin Moksnes and Petter Christian Borchgrevink and Stein Kaasa and Ola Dale},
  journal={Acta Anaesthesiologica Scandinavica},
  year={2008},
  volume={52}
}
Background: This topical review addresses methadone's pharmacology, its application in malignant and non‐malignant pain conditions, practical issues related to methadone for the treatment of pain and its influence on QTc time. 
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Methadone was first approved for clinical use in the United States in 1972. It is currently indicated for the treatment of moderate to severe pain, for detoxification of opiate addiction, and for
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