Clinical pharmacology of imipenem and cilastatin in premature infants during the first week of life.

@article{Reed1990ClinicalPO,
  title={Clinical pharmacology of imipenem and cilastatin in premature infants during the first week of life.},
  author={M. D. Walter Reed and Robert M Kliegman and Toyoko S Yamashita and Carolyn M Myers and Jeffrey L. Blumer},
  journal={Antimicrobial agents and chemotherapy},
  year={1990},
  volume={34 6},
  pages={1172-7}
}
The first-dose and multidose pharmacokinetics of imipenem and cilastatin were evaluated in 41 premature infants during their first week of life. Premature infants (gestational age, less than or equal to 37 weeks) were assigned to receive 10-, 15-, 20-, or 25-mg/kg doses of imipenem-cilastatin (1:1) as a single- or multiple-dose regimen. A total of 39 infants received a single dose, whereas 18 infants received multiple doses. No differences were observed in pharmacokinetic parameter estimates… CONTINUE READING