Clinical pharmacology of bleomycin and cisplatin.

  title={Clinical pharmacology of bleomycin and cisplatin.},
  author={W. Evans and G. Yee and W. Crom and C. Pratt and A. Green},
  journal={Drug intelligence & clinical pharmacy},
  volume={16 6},
  • W. Evans, G. Yee, +2 authors A. Green
  • Published 1982
  • Medicine
  • Drug intelligence & clinical pharmacy
  • Bleomycin (Blenoxane) and cisplatin (Platinol) are two anticancer drugs, with activity for head and neck tumors, that were introduced into clinical use in the past ten years. Bleomycin is used primarily in the chemotherapy of squamous cell carcinomas, lymphomas, and testicular carcinoma, while cisplatin possesses significant activity against testicular and ovarian carcinoma, head and neck cancer, bladder cancer, and neuroblastoma. Bleomycin is rapidly excreted renally (terminal phase half-life… CONTINUE READING
    32 Citations
    Aging increases the susceptibility of cisplatin-induced nephrotoxicity
    • 24
    • PDF
    The effect of prior cisplatin therapy on the pharmacokinetics of high-dose methotrexate.
    • W. Crom, C. Pratt, +4 authors W. Evans
    • Medicine
    • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    • 1984
    • 38
    Cisplatin‐Induced Ototoxicity: The Effect of Pigmentation and Inhibitory Agents
    • 130
    Ototoxicity of Cisplatin vs. Platinum Analogs CBDCA (JM-8) and CHIP (JM-9)
    • 46


    Clinical trials with bleomycin in lymphomas and in solid tumors.
    • 89
    Cytotoxic drug-induced pulmonary disease: update 1980.
    • 172