Clinical pharmacology of artemisinin-based combination therapies.

  title={Clinical pharmacology of artemisinin-based combination therapies.},
  author={Polina German and Francesca T. Aweeka},
  journal={Clinical pharmacokinetics},
  volume={47 2},
Malaria, a disease transmitted by the female Anopheles mosquito, has had devastating effects on human populations for more than 4000 years. Treatment of the disease with single drugs, such as chloroquine, sulfadoxine/pyrimethamine or mefloquine, has led to the emergence of resistant Plasmodium falciparum parasites that lead to the most severe form of the illness. Artemisinin-based combination therapies are currently recommended by WHO for the treatment of uncomplicated P. falciparum malaria… CONTINUE READING
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