Clinical pharmacology and toxicity of 4'-O-tetrahydropyranyladriamycin.

@article{Miller1987ClinicalPA,
  title={Clinical pharmacology and toxicity of 4'-O-tetrahydropyranyladriamycin.},
  author={Antonius A. Miller and Carl Gottfried Schmidt},
  journal={Cancer research},
  year={1987},
  volume={47 5},
  pages={1461-5}
}
The clinical pharmacology and toxicity of a novel anthracycline derivative, 4'-O-tetrahydropyranyladriamycin (THP-adriamycin), was investigated in patients with advanced malignant diseases. The starting dose was 30 mg/m2 which was escalated by increments of 10 mg/m2. Twelve patients with a median age of 42 (range, 19-69) years and a median Eastern Cooperative Oncology Group performance score of 2 (range, 1-2) were entered into the study. The diagnoses included four testicular cancers, two… CONTINUE READING

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