Clinical pharmacology and pharmacogenetics of thiopurines

@article{Sahasranaman2008ClinicalPA,
  title={Clinical pharmacology and pharmacogenetics of thiopurines},
  author={S. Sahasranaman and D. Howard and S. Roy},
  journal={European Journal of Clinical Pharmacology},
  year={2008},
  volume={64},
  pages={753-767}
}
The thiopurine drugs—azathioprine (AZA), 6-mercaptopurine (6-MP), and thioguanine—are widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. However, thiopurine drugs have a relatively narrow therapeutic index and are capable of causing life-threatening toxicity, most often myelosuppression. Thiopurine S-methyltransferase (TPMT; EC 2.1.1.67), an enzyme that catalyzes S-methylation of these drugs, exhibits… Expand
Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases
Thiopurine therapy in inflammatory bowel disease
Individually administered or co-prescribed thiopurines and mesalamines for inflammatory bowel disease.
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