Clinical pharmacology and pharmacogenetics of thiopurines

@article{Sahasranaman2008ClinicalPA,
  title={Clinical pharmacology and pharmacogenetics of thiopurines},
  author={Srikumar Sahasranaman and Danny Howard and Sandip Roy},
  journal={European Journal of Clinical Pharmacology},
  year={2008},
  volume={64},
  pages={753-767}
}
  • Srikumar Sahasranaman, Danny Howard, Sandip Roy
  • Published 2008
  • Medicine
  • European Journal of Clinical Pharmacology
  • The thiopurine drugs—azathioprine (AZA), 6-mercaptopurine (6-MP), and thioguanine—are widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. However, thiopurine drugs have a relatively narrow therapeutic index and are capable of causing life-threatening toxicity, most often myelosuppression. Thiopurine S-methyltransferase (TPMT; EC 2.1.1.67), an enzyme that catalyzes S-methylation of these drugs, exhibits… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 286 CITATIONS, ESTIMATED 49% COVERAGE

    Thiopurine therapy in inflammatory bowel disease

    FILTER CITATIONS BY YEAR

    2008
    2020

    CITATION STATISTICS

    • 15 Highly Influenced Citations

    • Averaged 20 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 151 REFERENCES

    Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase.

    The clinical pharmacology of 6-mercaptopurine

    • Lynne Lennard
    • Medicine
    • European Journal of Clinical Pharmacology
    • 2005