Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?

@article{Mannargudi2017ClinicalPA,
  title={Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?},
  author={Mukundan Baskar Mannargudi and S. Deb},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2017},
  volume={143},
  pages={1499-1529}
}
PurposeRibonucleotide reductase (RR) enzymes (RR1 and RR2) play an important role in the reduction of ribonucleotides to deoxyribonucleotides which is involved in DNA replication and repair. Augmented RR activity has been ascribed to uncontrolled cell growth and tumorigenic transformation.MethodsThis review mainly focuses on several biological and chemical RR inhibitors (e.g., siRNA, GTI-2040, GTI-2501, triapine, gemcitabine, and clofarabine) that have been evaluated in clinical trials with… Expand
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References

SHOWING 1-10 OF 315 REFERENCES
Ribonucleotide reductase inhibitors and future drug design.
Targeting ribonucleotide reductase for cancer therapy
Ribonucleotide Reductase Inhibitors: A New Look at an Old Target for Radiosensitization
Enhanced effects of adriamycin by combination with a new ribonucleotide reductase inhibitor, trimidox, in murine leukemia.
Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells
Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells
Ribonucleotide reductase: a critical enzyme for cancer chemotherapy and antiviral agents.
New ribonucleotide reductase inhibitors with antineoplastic activity.
Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd).
...
1
2
3
4
5
...