Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders

@article{Muehlan2020ClinicalPE,
  title={Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders},
  author={Clemens Muehlan and Cedric Vaillant and Isabelle Zenklusen and Stephan Kraehenbuehl and Jasper Dingemanse},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2020},
  volume={16},
  pages={1063 - 1078}
}
ABSTRACT Introduction The last two decades have witnessed a rapid increase in the knowledge about the role of the orexin system, particularly in the regulation of wakefulness and arousal. Dual orexin receptor antagonists (DORAs) have been approved for the treatment of insomnia disorders (suvorexant, lemborexant) and drugs with a distinctive profile (daridorexant) or orexin-2 receptor selectivity (seltorexant) are in development. Areas covered This review discusses pharmacokinetics (PK… 

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