Clinical pharmacokinetics of vindesine

  title={Clinical pharmacokinetics of vindesine},
  author={Robert L. Nelson and R. W. Dyke and Mary A. Root},
  journal={Cancer Chemotherapy and Pharmacology},
The pharmacokinetics of vindesine were investigated in five patients with advanced cancer who were receiving the drug. Following a rapid IV bolus dose, vindesine kinetics were described by a triphasic serum decay curve compatible with a three-compartment open mammillary model. Serum half-lives were 2 min, 50 min, and 24 h for the fast, middle, and slow… CONTINUE READING