Clinical pharmacokinetics of the salicylates.

  title={Clinical pharmacokinetics of the salicylates.},
  author={C. J. Needs and Peter M Brooks},
  journal={Clinical pharmacokinetics},
  volume={10 2},
The use of salicylates in rheumatic diseases has been established for over 100 years. The more recent recognition of their modification of platelet and endothelial cell function has lead to their use in other areas of medicine. Aspirin (acetylsalicylic acid) is still the most commonly used salicylate. After oral administration as an aqueous solution aspirin is rapidly absorbed at the low pH of the stomach millieu. Less rapid absorption is observed with other formulations due to the rate… CONTINUE READING
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