Clinical pharmacokinetics of the eye. Proctor lecture.

  title={Clinical pharmacokinetics of the eye. Proctor lecture.},
  author={Saiichi Mishima},
  journal={Investigative ophthalmology & visual science},
  volume={21 4},
  • Saiichi Mishima
  • Published 1981 in Investigative ophthalmology & visual science
Pharmacokinetics of instilled drugs in the human eye is reviewed. The behavior of drugs in the conjunctival cul-de-sac is discussed, and the loss rates with various vehicles are estimated. Kinetics of intraocular drug penetration follows the same pattern in human and rabbit eyes. From results of rabbit experiments, various pharmacokinetic coefficients are computed, including the permeability of the corneal epithelium. Also, with use of published data in human aqueous, the corneal permeability… CONTINUE READING
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