Clinical pharmacokinetics of the antitumor drug navelbine (5'-noranhydrovinblastine).

  title={Clinical pharmacokinetics of the antitumor drug navelbine (5'-noranhydrovinblastine).},
  author={Roger Rahmani and Rene Bruno and Athanassios Iliadis and Roger Favre and S. Just and Jacques Barbet and Jean Paul Cano},
  journal={Cancer research},
  volume={47 21},
Eleven patients with advanced cancer received navelbine (15 mg/m2) as a single i.v. bolus injection. At least 1 week later, the patients were given a 2-fold increased dose of navelbine (30 mg/m2) and, for seven of them, the 30-mg/m2 dose was repeated after a delay longer than a week. After each administration, plasma and urine were collected for 72 h and monitored for navelbine concentration by radioimmunoassay. The comparison of dose-normalized plasma level profiles showed significant time… CONTINUE READING


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